Holmes had won a brief pause delaying the start of her prison term while the appeals court considered her request. She can still pursue her appeal of her conviction, but must do so from prison.
Elizabeth Holmes lost her final request to remain free on bail while she appeals her fraud conviction.
The ruling Tuesday by the US Court of Appeals in San Francisco means the Theranos Inc. founder will soon have to report to prison to begin her 11 1/4-year sentence after she was convicted by a jury last year of defrauding investors in the blood-testing startup.
